article Open AccessTop 1% cited
Impairment of paravascular clearance pathways in the aging brain
Annals of Neurology · 2014 · Vol. 76(6) · pp. 845–861
Benjamin T. Kress(University of Rochester)Jeffrey J. Iliff✉(University of Rochester)Maosheng Xia(University of Rochester)Minghuan Wang(University of Rochester)Helen Wei(University of Rochester)Douglas Zeppenfeld(Oregon Health & Science University)Lulu Xie(University of Rochester)Hongyi Kang(University of Rochester)Qiwu Xu(University of Rochester)Jason Liew(University of Rochester)Benjamin A. Plog(University of Rochester)Fengfei Ding(University of Rochester)Rashid Deane(University of Rochester)Maiken Nedergaard(University of Rochester)
Abstract
We propose that impaired glymphatic clearance contributes to cognitive decline among the elderly and may represent a novel therapeutic target for the treatment of neurodegenerative diseases associated with accumulation of misfolded protein aggregates.
Cerebrospinal fluid and hydrocephalusTraumatic Brain Injury and Neurovascular DisturbancesAdvanced Neuroimaging Techniques and ApplicationsGlymphatic systemInterstitial fluidCerebrospinal fluidAquaporin 4ParenchymaIn vivoPathologyMedicineEvans BlueChemistry
MeSH terms
AgingAnimalsBrainCerebrovascular CirculationFemaleMaleMetabolic Clearance RateMice, Inbred C57BLNeurogliaMicroscopy, Fluorescence, MultiphotonMiceAquaporin 4
Funding
- American Heart Association
- Israel Science Foundation
- National Institutes of Health
- National Institute on Aging
- National Institute of Neurological Disorders and Stroke
Citations
1,434
FWCI
23.66
field-weighted impact
References
42
Percentile
100%
vs. same field & year
Citations per year
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References
Specialized Membrane Domains for Water Transport in Glial Cells: High-Resolution Immunogold Cytochemistry of Aquaporin-4 in Rat Brain
Journal of Neuroscience · 1997 · 1,441 citations
Protein aggregation and neurodegenerative disease
Nature Medicine · 2004 · 3,433 citations
Evidence for a ‘Paravascular’ fluid circulation in the mammalian central nervous system, provided by the rapid distribution of tracer protein throughout the brain from the subarachnoid space
Brain Research · 1985 · 766 citations
Transport Pathways for Clearance of Human Alzheimer's Amyloid β-Peptide and Apolipoproteins E and J in the Mouse Central Nervous System
Journal of Cerebral Blood Flow & Metabolism · 2006 · 667 citations
JUNCTIONS BETWEEN INTIMATELY APPOSED CELL MEMBRANES IN THE VERTEBRATE BRAIN
The Journal of Cell Biology · 1969 · 2,468 citations
Risk Factors for Alzheimer's Disease: A Prospective Analysis from the Canadian Study of Health and Aging
American Journal of Epidemiology · 2002 · 1,260 citations
Structure and function of aquaporin water channels
American Journal of Physiology-Renal Physiology · 2000 · 751 citations
A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid β
Science Translational Medicine · 2012 · 5,356 citations
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