review Open AccessTop 1% cited
The effect of methotrexate on cardiovascular disease in patients with rheumatoid arthritis: a systematic literature review
Lara D. Veeken · 2009 · Vol. 49(2) · pp. 295–307
Sarah Westlake✉(Poole Hospital NHS Foundation Trust)Alexandra N. ColebatchJanis BairdPatrick KielyMark QuinnErnest ChoyA. J. OstorC J Edwards
Abstract
The current evidence suggests that MTX use is associated with a reduced risk of CVD events in patients with RA. This suggests that reducing the inflammation in RA using MTX not only improves disease-specific outcomes but may also reduce collateral damage such as atherosclerosis.
Rheumatoid Arthritis Research and TherapiesSystemic Lupus Erythematosus ResearchChronic Lymphocytic Leukemia ResearchMedicineRheumatoid arthritisMethotrexateDiseaseInternal medicineArthritisSystematic reviewMEDLINE
MeSH terms
Arthritis, RheumatoidCardiovascular DiseasesHumansImmunosuppressive AgentsInsulin ResistanceLipidsMethotrexateAntirheumatic Agents
Citations
355
FWCI
16.26
field-weighted impact
References
57
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100%
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References
Cardiovascular death in rheumatoid arthritis: A population‐based study
Arthritis & Rheumatism · 2005 · 937 citations
Mortality in rheumatoid arthritis. Increased in the early course of disease, in ischaemic heart disease and in pulmonary fibrosis
Lara D. Veeken · 2006 · 351 citations
Rosuvastatin to Prevent Vascular Events in Men and Women with Elevated C-Reactive Protein
New England Journal of Medicine · 2008 · 6,562 citations
Tools for assessing quality and susceptibility to bias in observational studies in epidemiology: a systematic review and annotated bibliography
International Journal of Epidemiology · 2007 · 1,538 citations
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