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SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27

Nature Cell Biology · 1999 · Vol. 1(4) · pp. 193–199

Andrea C. Carrano✉(Columbia University Irving Medical Center)Esther Eytan(Technion – Israel Institute of Technology)Avram Hershko(Technion – Israel Institute of Technology)Michele Pagano(Columbia University Irving Medical Center)

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Cancer-related Molecular Pathways Ubiquitin and proteasome pathways Microtubule and mitosis dynamicsCyclin-dependent kinaseUbiquitin ligaseCell biologyUbiquitinSKP2CDK inhibitorPhosphorylationCyclin AF-box proteinCyclin E

MeSH terms

Base SequenceCell LineEnzyme InhibitorsHeLa CellsHumansKineticsMicrotubule-Associated ProteinsPhosphorylationProtein BindingRNA, MessengerUbiquitinsCell Cycle ProteinsCyclin-Dependent KinasesOligodeoxyribonucleotides, AntisenseTumor Suppressor Proteins

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The Ubiquitin-Proteasome Proteolytic Pathway: Destruction for the Sake of Construction