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Novel selective small molecule agonists for peroxisome proliferator-activated receptor δ (PPARδ)—synthesis and biological activity
Bioorganic & Medicinal Chemistry Letters · 2003 · Vol. 13(9) · pp. 1517–1521
Marcos L. Sznaidman(GlaxoSmithKline (United States))Curt D. Haffner(GlaxoSmithKline (United States))Patrick Maloney(Research Triangle Park Foundation)Adam M. Fivush(GlaxoSmithKline (United States))Esther Y. Chao(GlaxoSmithKline (United States))Donna M. Goreham(GlaxoSmithKline (United States))Michael L. Sierra(GlaxoSmithKline (France))Christelle LeGrumelec(GlaxoSmithKline (France))H. Eric Xu(Research Triangle Park Foundation)Valerie G. Montana(GlaxoSmithKline (United States))Millard H. Lambert(Research Triangle Park Foundation)Timothy M. Willson(GlaxoSmithKline (United States))William R. Oliver(Research Triangle Park Foundation)Daniel D. Sternbach✉(GlaxoSmithKline (United States))
Peroxisome Proliferator-Activated ReceptorsAdenosine and Purinergic SignalingMetabolism, Diabetes, and CancerChemistryPeroxisome proliferator-activated receptorPeroxisomeAgonistReceptorBiological activityPartial agonistBiochemistrySmall moleculePPAR agonist
MeSH terms
AnimalsCells, CulturedHumansPhenolsRadioligand AssayStructure-Activity RelationshipSulfhydryl CompoundsThiazolesTranscription FactorsTranscriptional ActivationReceptors, Cytoplasmic and NuclearCombinatorial Chemistry TechniquesMice
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311
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17
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References
The PPARs: From Orphan Receptors to Drug Discovery
Journal of Medicinal Chemistry · 2000 · 1,799 citations
Identification of a new member of the steroid hormone receptor superfamily that is activated by a peroxisome proliferator and fatty acids.
Molecular Endocrinology · 1992 · 457 citations
An Antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activated Receptor γ (PPARγ)
Journal of Biological Chemistry · 1995 · 3,617 citations
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