article Open AccessTop 10% cited
Hypoxia induces epithelial-mesenchymal transition via activation of SNAI1 by hypoxia-inducible factor -1α in hepatocellular carcinoma
BMC Cancer · 2013 · Vol. 13(1) · pp. 108–108
Lin Zhang(Army Medical University)Gang Huang(Army Medical University)Xiaowu Li(Army Medical University)Yujun Zhang(Southwest Hospital)Yan Jiang(Army Medical University)Junjie Shen(Southwest Hospital)Jia Liu(Army Medical University)Qingliang Wang(Army Medical University)Jin Zhu(Army Medical University)Xiaobin Feng(Army Medical University)Jiahong Dong✉Cheng Qian(Southwest Hospital)
Abstract
We demonstrated that hypoxia-stabilized HIF1α promoted EMT through increasing SNAI1 transcription in HCC cells. This data provided a potential therapeutic target for HCC treatment.
Cancer, Hypoxia, and MetabolismCancer Cells and MetastasisFibroblast Growth Factor ResearchSNAI1Epithelial–mesenchymal transitionCancer researchVimentinHepatocellular carcinomaHypoxia (environmental)MetastasisTranscription factorHypoxia-inducible factorsMedicine
MeSH terms
Snail Family Transcription FactorsHypoxiaCell CycleCell MovementCobaltCarcinoma, HepatocellularHumansLiver NeoplasmsPrognosisTranscription FactorsTranscription, GeneticVimentinCadherinsGene ExpressionGene Expression Regulation, Neoplastic
Funding
- National Key Research and Development Program of China
Citations
293
FWCI
9.44
field-weighted impact
References
53
Percentile
99%
vs. same field & year
Citations per year
References
The Hallmarks of Cancer
Cell · 2000 · 28,385 citations
Direct regulation of TWIST by HIF-1α promotes metastasis
Nature Cell Biology · 2008 · 1,329 citations
Mechanisms of metastasis: Epithelial‐to‐mesenchymal transition and contribution of tumor microenvironment
Journal of Cellular Biochemistry · 2007 · 367 citations
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