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A novel VNTR enhancer within the SIRT3 gene, a human homologue of SIR2, is associated with survival at oldest ages

Genomics · 2004 · Vol. 85(2) · pp. 258–263

Dina Bellizzi(University of Calabria)Giuseppina Rose(University of Calabria)Paola Cavalcante(University of Calabria)Giuseppina Covello(University of Calabria)Serena Dato(University of Calabria)Francesco De Rango(University of Calabria)Valentina Greco(University of Calabria)Marcello Maggiolini(University of Calabria)E Feraco(Istituto Nazionale di Riposo e Cura per Anziani)Vincenzo Mari(Istituto Nazionale di Riposo e Cura per Anziani)Claudio Franceschi(University of Bologna)Giuseppe Passarino(University of Calabria)Giovanna De Benedictis✉(University of Calabria)

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Sirtuins and Resveratrol in Medicine Biochemical effects in animals Adipose Tissue and MetabolismBiologyEnhancerSirtuinLongevityGeneticsSIRT3AlleleGeneIntronGene expression

MeSH terms

AdultAgedAged, 80 and overBase SequenceEnhancer Elements, GeneticFemaleHistone DeacetylasesHumansLongevityMaleMiddle AgedMolecular Sequence DataPolymorphism, GeneticMinisatellite RepeatsMitochondrial Proteins

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Mammalian Sir2 Homolog SIRT3 Regulates Global Mitochondrial Lysine Acetylation