article Open AccessTop 1% cited
Mutations in the K+ channel signature sequence
Biophysical Journal · 1994 · Vol. 66(4) · pp. 1061–1067
Lise Heginbotham✉(Harvard University)Zheming Lu(Harvard University)Tatiana Abramson(Harvard University)Roderick MacKinnon(Harvard University)
Ion channel regulation and functionNeuroscience and Neuropharmacology ResearchNicotinic Acetylcholine Receptors StudySelectivityThreonineSequence (biology)KcsA potassium channelChemistryPotassium channelTyrosineShakerPeptide sequenceStereochemistry
MeSH terms
Amino Acid SequenceAnimalsBiophysicsDrosophilaFemaleMolecular Sequence DataMutationOocytesPhenotypePotassiumXenopus laevisPotassium ChannelsMutagenesis, Site-DirectedConserved SequenceSequence Homology, Amino Acid
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99%
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References
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Negative Conductance Caused by Entry of Sodium and Cesium Ions into the Potassium Channels of Squid Axons
The Journal of General Physiology · 1972 · 550 citations
Rapid and efficient site-specific mutagenesis without phenotypic selection.
Proceedings of the National Academy of Sciences · 1985 · 7,319 citations
The effect of sodium ions on the electrical activity of the giant axon of the squid
The Journal of Physiology · 1949 · 3,517 citations
Inactivation of the sodium channel. I. Sodium current experiments.
The Journal of General Physiology · 1977 · 1,504 citations
DNA sequencing with chain-terminating inhibitors
Proceedings of the National Academy of Sciences · 1977 · 69,196 citations
POTENTIAL, IMPEDANCE, AND RECTIFICATION IN MEMBRANES
The Journal of General Physiology · 1943 · 2,784 citations
Potassium Channels in Myelinated Nerve
The Journal of General Physiology · 1973 · 448 citations
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