articleTop 1% cited

Correlation between in vitro and in vivo immunomodulatory properties of lactic acid bacteria

World Journal of Gastroenterology · 2007 · Vol. 13(2) · pp. 236–236

Abstract

These results show that we could predict the in vivo protective capacity of the studied lactic acid bacteria (LAB) based on the cytokine profile we established in vitro. The PBMC-based assay we used may thus serve as a useful primary indicator to narrow down the number of candidate strains to be tested in murine models for their anti-inflammatory potential.

Probiotics and Fermented Foods Microbial Metabolites in Food Biotechnology Digestive system and related healthIn vivoCytokinePeripheral blood mononuclear cellTumor necrosis factor alphaColitisIn vitroEx vivoLactic acidInterleukin 10Probiotic

MeSH terms

AnimalsColitisColonDisease Models, AnimalHumansLactobacillusLeukocytes, MononuclearMice, Inbred BALB CTrinitrobenzenesulfonic AcidCytokinesProbioticsMice

Citations

424

FWCI

37.16

field-weighted impact

References

Percentile

100%

vs. same field & year

Citations per year

Cited by

<i>Faecalibacterium prausnitzii</i> is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients