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Fetal Mesenchymal Stem-Cell Engraftment in Bone after In Utero Transplantation in a Patient with Severe Osteogenesis Imperfecta
Transplantation · 2005 · Vol. 79(11) · pp. 1607–1614
Katarina Le Blanc✉(Karolinska University Hospital)Cecilia Götherström(Karolinska University Hospital)Olle Ringdén(Karolinska Institutet)Moustapha HassanRobert P. McMahonEdwin M. HorwitzGöran Annerén(Uppsala University)Ove Axelssön(Uppsala University)Janice NunnUwe Ewald(Uppsala University)Solveig Nordén‐Lindeberg(Uppsala University)Monika JanssonAnn DaltonEva ÅströmMagnus Westgren
Abstract
The authors' findings show that allogeneic fetal MSC can engraft and differentiate into bone in a human fetus even when the recipient is immunocompetent and HLA-incompatible.
Mesenchymal stem cell researchNeurogenetic and Muscular Disorders ResearchBone fractures and treatmentsOsteogenesis imperfectaMesenchymal stem cellMedicineTransplantationFetusPathologyBone marrowOsteopontinImmunologyInternal medicine
MeSH terms
AdultBiopsyBone and BonesCollagenFemaleGestational AgeHLA-DR AntigensHumansInfantInfant, NewbornMaleMesodermOsteogenesis ImperfectaPregnancyPregnancy Complications
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