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Mesenchymal Stem Cells for Treatment of Therapy-Resistant Graft-versus-Host Disease
Transplantation · 2006 · Vol. 81(10) · pp. 1390–1397
Olle Ringdén✉(Karolinska Institutet)Mehmet Uzunel(Weatherford College)Ida Rasmusson(Karolinska Institutet)Mats Remberger(Karolinska Institutet)Berit Sundberg(Karolinska Institutet)Helena Lönnies(Karolinska University Hospital)Hanns–Ulrich Marschall(Karolinska Institutet)Aldona Dlugosz(Karolinska Institutet)Attila Szakos(Karolinska University Hospital)Zuzana Hassan(Karolinska Institutet)Brigitta Omazic(Karolinska University Hospital)J Aschan(Karolinska Institutet)Lisbeth Barkholt(Karolinska University Hospital)Katarina Le Blanc(Karolinska Institutet)
Abstract
MSC is a very promising treatment for severe steroid-resistant acute GVHD.
Mesenchymal stem cell researchHematopoietic Stem Cell TransplantationVirus-based gene therapy researchMedicineGraft-versus-host diseaseMesenchymal stem cellGastroenterologySurgeryTransplantationLymphomaInternal medicinePathology
MeSH terms
AdultAnimalsChildDNAFemaleGraft vs Host DiseaseHumansImmunotherapyIntestinal MucosaMaleMiddle AgedPilot ProjectsSteroidsTissue DonorsTreatment Outcome
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References
Nonmyeloablative Stem Cell Transplantation and Cell Therapy as an Alternative to Conventional Bone Marrow Transplantation With Lethal Cytoreduction for the Treatment of Malignant and Nonmalignant Hematologic Diseases
Blood · 1998 · 1,939 citations
Mesenchymal stem cells inhibit lymphocyte proliferation by mitogens and alloantigens by different mechanisms
Experimental Cell Research · 2005 · 495 citations
Bone marrow mesenchymal stem cells inhibit the response of naive and memory antigen-specific T cells to their cognate peptide
Blood · 2003 · 1,588 citations
Suppression of allogeneic T-cell proliferation by human marrow stromal cells: implications in transplantation
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Mesenchymal stem cells inhibit the formation of cytotoxic T lymphocytes, but not activated cytotoxic T lymphocytes or natural killer cells
Transplantation · 2003 · 663 citations
Fetal Mesenchymal Stem-Cell Engraftment in Bone after In Utero Transplantation in a Patient with Severe Osteogenesis Imperfecta
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Human mesenchymal stem cells modulate allogeneic immune cell responses
Blood · 2004 · 4,508 citations
Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli
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