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Intestinal Dysbiosis: A Possible Mechanism of Alcohol‐Induced Endotoxemia and Alcoholic Steatohepatitis in Rats

Alcoholism Clinical and Experimental Research · 2009 · Vol. 33(10) · pp. 1836–1846

Ece Mutlu✉(Rush University Medical Center)Ali Keshavarzian(Rush University Medical Center)Phillip A. Engen(Rush University Medical Center)Christopher B. Forsyth(Rush University Medical Center)Masoumeh Sikaroodi(Rush University Medical Center)Patrick M. Gillevet(Rush University Medical Center)

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Abstract

Daily alcohol consumption for 10 weeks alters colonic mucosa-associated bacterial microbiota composition in rats. Our data showed, for the first time, that daily alcohol consumption can affect colonic microbiome composition and suggest that dysbiosis may be an important mechanism of alcohol-induced endotoxemia. Further studies are needed to determine how dysbiotic microbiota contributes to development of ALD and whether therapeutic interventions targeted towards dysbiotic microbiota can prevent complications of alcoholism like ALD.

Gut microbiota and health Diet and metabolism studies Liver Disease Diagnosis and TreatmentDysbiosisGut floraAlcoholMicrobiomeSteatohepatitisPrebioticInternal medicineBiologyAlcoholic liver diseaseLactobacillus

MeSH terms

EthanolAnimalsCentral Nervous System DepressantsColonDietFatty Liver, AlcoholicGlucoseIleumIntestinal AbsorptionIntestinesMalePeptide MappingPermeabilityRats, Sprague-DawleyOxidative Stress