reviewTop 1% cited
Exploiting the PI3K/AKT Pathway for Cancer Drug Discovery
Nature Reviews Drug Discovery · 2005 · Vol. 4(12) · pp. 988–1004
Bryan T. Hennessy✉(The University of Texas MD Anderson Cancer Center)Debra L. Smith(The University of Texas Health Science Center at Houston)Prahlad T. Ram(Center for Systems Biology)Yiling Lu(The University of Texas MD Anderson Cancer Center)Gordon B. Mills(The University of Texas MD Anderson Cancer Center)
PI3K/AKT/mTOR signaling in cancerBiochemical and Molecular ResearchChronic Lymphocytic Leukemia ResearchPI3K/AKT/mTOR pathwayDrug discoveryProtein kinase BChromosomal translocationCancer researchTargeted therapyCancerPhosphatidylinositolDrugComputational biology
MeSH terms
AnimalsAntineoplastic AgentsDrug EvaluationGene AmplificationHumansMutationTranslocation, GeneticDrug DesignSignal TransductionPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-akt
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