article Open AccessTop 10% cited
Synthesis and biological evaluation of pyrazole derivatives containing thiourea skeleton as anticancer agents
Bioorganic & Medicinal Chemistry · 2010 · Vol. 18(13) · pp. 4606–4614
Peng‐Cheng Lv(Nanjing University)Huan‐Qiu Li(Nanjing University)Juan Sun(Nanjing University)Yang Zhou(Nanjing University)Hai‐Liang Zhu✉(Nanjing University)
Synthesis and biological activityHER2/EGFR in Cancer ResearchCytokine Signaling Pathways and InteractionsPyrazoleChemistryThioureaErlotinibDocking (animal)StereochemistryStructure–activity relationshipEGFR inhibitorsBiological activityIn vitro
MeSH terms
Antineoplastic AgentsBinding SitesComputer SimulationHumansNeoplasmsPyrazolesThioamidesThioureaCell Line, TumorErbB Receptors
Funding
- National Natural Science Foundation of China
Citations
278
FWCI
8.25
field-weighted impact
References
30
Percentile
98%
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Citations per year
Cited by
Recent applications of pyrazole and its substituted analogs
International journal of applied research · 2016 · 5 citations
References
Substituent Effects on the Antibacterial Activity of Nitrogen−Carbon-Linked (Azolylphenyl)oxazolidinones with Expanded Activity Against the Fastidious Gram-Negative Organisms <i>Haemophilus </i><i>i</i><i>nfluenzae</i> and <i>Moraxella </i><i>c</i><i>atarrhalis</i>
Journal of Medicinal Chemistry · 2000 · 723 citations
Signal transduction by receptors with tyrosine kinase activity
Cell · 1990 · 5,517 citations
Synthesis and Biological Evaluation of the 1,5-Diarylpyrazole Class of Cyclooxygenase-2 Inhibitors: Identification of 4-[5-(4-Methylphenyl)-3- (trifluoromethyl)-1<i>H</i>-pyrazol-1-yl]benzenesulfonamide (SC-58635, Celecoxib)
Journal of Medicinal Chemistry · 1997 · 1,949 citations
Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2/<i>neu</i>Oncogene
Science · 1987 · 11,680 citations
Identification of antitumor activity of pyrazole oxime ethers
Bioorganic & Medicinal Chemistry Letters · 2005 · 313 citations
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