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Systemic inflammation and disease progression in Alzheimer disease
Neurology · 2009 · Vol. 73(10) · pp. 768–774
Clive Holmes✉(Moorgreen Hospital)Colm Cunningham(Moorgreen Hospital)E. Zotova(Moorgreen Hospital)Janet Woolford(Moorgreen Hospital)C. Dean(Moorgreen Hospital)Steven Kerr(Moorgreen Hospital)David Culliford(Moorgreen Hospital)V. Hugh Perry(Moorgreen Hospital)
Abstract
Both acute and chronic systemic inflammation, associated with increases in serum tumor necrosis factor alpha, is associated with an increase in cognitive decline in Alzheimer disease.
Alzheimer's disease research and treatmentsTryptophan and brain disordersNeuroinflammation and Neurodegeneration MechanismsDiseaseInflammationMedicineAlzheimer's diseaseSystemic inflammationPathologyImmunology
MeSH terms
Acute DiseaseAgedAged, 80 and overAlzheimer DiseaseChronic DiseaseCognition DisordersFemaleFollow-Up StudiesHumansMaleProspective StudiesRetrospective StudiesTumor Necrosis Factor-alphaCohort StudiesBiomarkers
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