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A General, Efficient, and Inexpensive Catalyst System for the Coupling of Aryl Iodides and Thiols

Organic Letters · 2002 · Vol. 4(20) · pp. 3517–3520
Fuk Yee KwongStephen L. Buchwald

Abstract

An efficient copper-catalyzed carbon-sulfur bond formation reaction was developed. This method is particularly noteworthy given its experimental simplicity, high generality, and exceptional level of functional group toleration and the low cost of the catalyst system. [reaction: see text]

Sulfur-Based Synthesis TechniquesChemical Synthesis and ReactionsCatalytic Cross-Coupling ReactionsChemistryCatalysisArylSimplicityGeneralityCombinatorial chemistrySulfurFunctional groupCoupling reactionReaction conditions

MeSH terms

CatalysisChemistry, OrganicCopperIodidesSulfhydryl CompoundsMolecular Structure

Funding

  • Pfizer
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