articleTop 10% cited
The anti-inflammatory flavones quercetin and kaempferol cause inhibition of inducible nitric oxide synthase, cyclooxygenase-2 and reactive C-protein, and down-regulation of the nuclear factor kappaB pathway in Chang Liver cells
European Journal of Pharmacology · 2006 · Vol. 557(2-3) · pp. 221–229
María Victoria García‐Mediavilla(Universidad de León)Irene Crespo(Universidad de León)Pilar S. Collado(Universidad de León)A. Esteller(Universidad de Salamanca)Sonia Sánchez‐Campos(Universidad de León)María J. Tuñón(Universidad de León)Javier González‐Gallego✉(Universidad de León)
Natural product bioactivities and synthesisPhytochemistry and Biological ActivitiesBioactive natural compoundsKaempferolNitric oxide synthaseQuercetinNitric oxideChemistryCyclooxygenaseHepatocytePharmacologyBiochemistryBiology
MeSH terms
C-Reactive ProteinCell LineDose-Response Relationship, DrugHumansQuercetinMolecular StructureDown-RegulationNF-kappa BHepatocytesFlavonolsKaempferolsCyclooxygenase 2Nitric Oxide Synthase Type II
Citations
544
FWCI
5.29
field-weighted impact
References
67
Percentile
96%
vs. same field & year
Citations per year
Cited by
Flavones: An important scaffold for medicinal chemistry
European Journal of Medicinal Chemistry · 2014 · 520 citations
References
Antioxidant and pro-oxidant actions of the plant phenolics quercetin, gossypol and myricetin
Biochemical Pharmacology · 1989 · 559 citations
Suppression of inducible cyclooxygenase and inducible nitric oxide synthase by apigenin and related flavonoids in mouse macrophages
Carcinogenesis · 1999 · 568 citations
<i>In vivo</i> quercitrin anti‐inflammatory effect involves release of quercetin, which inhibits inflammation through down‐regulation of the NF‐κB pathway
European Journal of Immunology · 2005 · 632 citations
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