article Open AccessTop 1% cited
Through Ageing, and Beyond: Gut Microbiota and Inflammatory Status in Seniors and Centenarians
PLoS ONE · 2010 · Vol. 5(5) · pp. e10667–e10667
Elena Biagi✉(University of Bologna)Lotta Nylund(University of Turku)Marco Candela(University of Bologna)Rita Ostan(University of Bologna)Laura Bucci(University of Bologna)Elisa Pini(University of Bologna)Janne Nikkilä(University of Helsinki)Daniela Monti(University of Florence)Reetta Satokari(University of Turku)Claudio Franceschi(University of Bologna)Patrizia Brigidi(University of Bologna)Willem M. de Vos(University of Helsinki)
Abstract
We provide evidence for the fact that the ageing process deeply affects the structure of the human gut microbiota, as well as its homeostasis with the host's immune system. Because of its crucial role in the host physiology and health status, age-related differences in the gut microbiota composition may be related to the progression of diseases and frailty in the elderly population.
Gut microbiota and healthDiet and metabolism studiesDietary Effects on HealthBiologyGut floraFirmicutesAgeingHuman microbiomePopulationEubacteriumMicrobiomeDysbiosisMicrobiology
MeSH terms
AdultAgedAged, 80 and overAgingFecesFemaleHumansInflammationMalePhylogenyCluster AnalysisImmunophenotypingLymphocyte SubsetsPolymerase Chain ReactionCytokines
Funding
- Università di Bologna
Citations
1,450
FWCI
22.72
field-weighted impact
References
74
Percentile
100%
vs. same field & year
Citations per year
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References
Development and application of the human intestinal tract chip, a phylogenetic microarray: analysis of universally conserved phylotypes in the abundant microbiota of young and elderly adults
Environmental Microbiology · 2009 · 480 citations
Microbes in Gastrointestinal Health and Disease
Gastroenterology · 2008 · 1,367 citations
Development of an extensive set of 16S rDNA-targeted primers for quantification of pathogenic and indigenous bacteria in faecal samples by real-time PCR
Journal of Applied Microbiology · 2004 · 1,008 citations
Towards the human intestinal microbiota phylogenetic core
Environmental Microbiology · 2009 · 888 citations
The gut microbiota shapes intestinal immune responses during health and disease
Nature reviews. Immunology · 2009 · 4,944 citations
Interactions and competition within the microbial community of the human colon: links between diet and health
Environmental Microbiology · 2007 · 649 citations
Diversity, metabolism and microbial ecology of butyrate-producing bacteria from the human large intestine
FEMS Microbiology Letters · 2009 · 2,197 citations
Differences in Fecal Microbiota in Different European Study Populations in Relation to Age, Gender, and Country: a Cross-Sectional Study
Applied and Environmental Microbiology · 2006 · 1,005 citations
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