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Estimated glomerular filtration rate, chronic kidney disease and antiretroviral drug use in HIV-positive patients

AIDS · 2010 · Vol. 24(11) · pp. 1667–1678

Amanda Mocroft✉(University of London)Ole Kirk(University of Copenhagen)Peter Reiss(University of Amsterdam)Stéphane De Wit(Centre Hospitalier Universitaire de Saint-Pierre)Dalibor Sedláček(Charles University)Marek BeniowskiJosé M. Gatell(Hospital Clínic de Barcelona)Andrew Phillips(University College London)Bruno Ledergerber(University Hospital of Zurich)Jens Lundgren(University of Copenhagen)

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Abstract

In this nonrandomized large cohort, increasing exposure to tenofovir was associated with a higher incidence of CKD, as was true for indinavir and atazanavir, whereas the results for lopinavir/r were less clear.

HIV-related health complications and treatments HIV/AIDS drug development and treatment HIV/AIDS Research and InterventionsKidney diseaseAntiretroviral drugMedicineRenal functionHuman immunodeficiency virus (HIV)DrugSidaInternal medicineAntiretroviral therapyViral disease

MeSH terms

TenofovirAtazanavir SulfateAdenineAdultEpidemiologic MethodsFemaleGlomerular Filtration RateHIV SeropositivityHumansKidney Failure, ChronicMaleMiddle AgedOligopeptidesPyridinesHIV-1