articleTop 1% cited
Association of tenofovir exposure with kidney disease risk in HIV infection
AIDS · 2012 · Vol. 26(7) · pp. 867–875
Rebecca ScherzerMichelle M. Estrella(Johns Hopkins University)Yongmei Li(San Francisco VA Medical Center)Andy I. Choi(San Francisco VA Medical Center)Steven G. Deeks(San Francisco General Hospital)Carl Grünfeld(San Francisco VA Medical Center)Michael G. Shlipak✉(San Francisco VA Medical Center)
Abstract
Tenofovir exposure was independently associated with increased risk for three types of kidney disease events, and did not appear to be reversible. Because subtle kidney function decline affects long-term morbidity and mortality, the balance between efficacy and probable adverse effects requires further study.
HIV/AIDS drug development and treatmentHIV-related health complications and treatmentsHIV Research and TreatmentTenofovirMedicineHuman immunodeficiency virus (HIV)Kidney diseaseSidaInternal medicineVirologyViral disease
MeSH terms
TenofovirAdenineAdultFemaleFollow-Up StudiesGlomerular Filtration RateHumansKidney Failure, ChronicMaleMiddle AgedProteinuriaRisk FactorsTime FactorsHIV InfectionsTreatment Outcome
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References
Estimated glomerular filtration rate, chronic kidney disease and antiretroviral drug use in HIV-positive patients
AIDS · 2010 · 404 citations
A simplified equation to predict glomerular filtration rate from serum creatinine
Journal of the American Society of Nephrology · 2000 · 1,724 citations
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