article Open AccessTop 1% cited
High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells
Nature Biotechnology · 2013 · Vol. 31(9) · pp. 822–826
Yanfang Fu✉(Massachusetts General Hospital)Jennifer A Foden(Center for Cancer Research)Cyd Khayter(Center for Cancer Research)Morgan L. Maeder(Center for Cancer Research)Deepak Reyon(Center for Cancer Research)J. Keith Joung(Massachusetts General Hospital)Jeffry D. Sander(Center for Cancer Research)
CRISPR and Genetic EngineeringAdvanced biosensing and bioanalysis techniquesRNA and protein synthesis mechanismsCRISPRGuide RNACas9Genome editingBiologyRNAMutagenesisDNAComputational biologyPalindrome
MeSH terms
Base SequenceEndonucleasesGenetic EngineeringHumansMolecular Sequence DataMutagenesisK562 CellsHEK293 CellsCRISPR-Associated Proteins
Citations
3,285
FWCI
144.27
field-weighted impact
References
20
Percentile
100%
vs. same field & year
Citations per year
Cited by
Recent advances in plant gene therapy
International Journal of Research in Agronomy · 2025 · 0 citations
Concerning RNA-guided gene drives for the alteration of wild populations
eLife · 2014 · 897 citations
Highly Specific and Efficient CRISPR/Cas9-Catalyzed Homology-Directed Repair in <i>Drosophila</i>
Genetics · 2014 · 1,059 citations
Enhanced homology-directed human genome engineering by controlled timing of CRISPR/Cas9 delivery
eLife · 2014 · 1,227 citations
Multiplex Genome Editing to Generate Universal CAR T Cells Resistant to PD1 Inhibition
Clinical Cancer Research · 2016 · 917 citations
Multigene Editing in the Escherichia coli Genome via the CRISPR-Cas9 System
Applied and Environmental Microbiology · 2015 · 1,351 citations
mRNA-based therapeutics — developing a new class of drugs
Nature Reviews Drug Discovery · 2014 · 2,333 citations
CRISPR-Cas systems for editing, regulating and targeting genomes
Nature Biotechnology · 2014 · 3,157 citations
References
Efficient genome editing in zebrafish using a CRISPR-Cas system
Nature Biotechnology · 2013 · 2,984 citations
RNA-guided editing of bacterial genomes using CRISPR-Cas systems
Nature Biotechnology · 2013 · 2,476 citations
RNA-Guided Human Genome Engineering via Cas9
Science · 2013 · 9,293 citations
A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity
Science · 2012 · 16,935 citations
Multiplex Genome Engineering Using CRISPR/Cas Systems
Science · 2013 · 15,534 citations
Genome Engineering of <i>Drosophila</i> with the CRISPR RNA-Guided Cas9 Nuclease
Genetics · 2013 · 1,052 citations
RNA-programmed genome editing in human cells
eLife · 2013 · 2,139 citations
Citation Network
How this paper connects to the literature. Drag to explore, click any node to open that paper.