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Multipotent Flk-1+ Cardiovascular Progenitor Cells Give Rise to the Cardiomyocyte, Endothelial, and Vascular Smooth Muscle Lineages

Developmental Cell · 2006 · Vol. 11(5) · pp. 723–732
Steven KattmanTara L. HuberGordon Keller
Congenital heart defects researchPluripotent Stem Cells ResearchDevelopmental Biology and Gene RegulationBiologyBrachyuryProgenitor cellCell biologyPrimitive streakEmbryonic stem cellEndothelial stem cellPopulationProgenitorVascular smooth muscle

MeSH terms

Brachyury ProteinAnimalsCardiovascular SystemCell DifferentiationCells, CulturedFetal ProteinsMuscle, Smooth, VascularTranscription FactorsCell LineageT-Box Domain ProteinsMyocytes, CardiacMultipotent Stem CellsVascular Endothelial Growth Factor Receptor-2Endothelial CellsMice

Funding

  • National Institutes of Health
  • National Heart, Lung, and Blood Institute
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