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Relationship of Early Hyperglycemia to Mortality in Trauma Patients

The Journal of Trauma: Injury, Infection, and Critical Care · 2004 · Vol. 56(5) · pp. 1058–1062

Amanda M. Laird✉(Wake Forest University)Preston R. Miller(Wake Forest University)Patrick D. KilgoJ. Wayne MeredithMichael Chang

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Abstract

Early hyperglycemia as defined by glucose > or =200 mg/dL is associated with significantly higher infection and mortality rates in trauma patients independent of injury characteristics. This was not true at the cutoffs of > or =110 mg/dL or > or =150 mg/dL. These data support the need for a prospective analysis of tight glucose control, keeping serum glucose <200 mg/dL in critically ill trauma patients. However, aggressive maintenance of levels <110 mg/dL as reported by others may not be necessary.

Hyperglycemia and glycemic control in critically ill and hospitalized patients Sepsis Diagnosis and Treatment Cardiac Arrest and ResuscitationMedicineGlasgow Coma ScaleInjury Severity ScoreDiabetes mellitusInternal medicineTrauma centerPopulationSepsisUnivariate analysisMortality rate

MeSH terms

Academic Medical CentersAcid-Base ImbalanceAdultAnalysis of VarianceBlood GlucoseCritical CareCross InfectionFemaleHumansHyperglycemiaMaleMiddle AgedMultiple TraumaNorth CarolinaPredictive Value of Tests

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Persistent Hyperglycemia is Predictive of Outcome in Critically Ill Trauma Patients