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Intraoperative Detection of Malignant Gliomas by 5-Aminolevulinic Acid-induced Porphyrin Fluorescence

Neurosurgery · 1998 · Vol. 42(3) · pp. 518–526

S Walter✉(Ludwig-Maximilians-Universität München)Stocker SusanneWagner SimonHerbert SteppFritsch Clemens(Heinrich Heine University Düsseldorf)Goetz ClaudiaEmilia Alwin(Ludwig-Maximilians-Universität München)Kiefmann Rainer(Ludwig-Maximilians-Universität München)J. Reulen Hans

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Abstract

Our observations suggest that 5-aminolevulinic acid-induced porphyrin fluorescence may label malignant gliomas safely and accurately enough to enhance the completeness of tumor removal.

Photodynamic Therapy Research Studies Nanoplatforms for cancer theranostics Porphyrin and Phthalocyanine ChemistryPorphyrinFluorescenceMedicinePathologyFluorescence microscopeGliomaPhotochemistryChemistryCancer researchOptics

MeSH terms

AgedAminolevulinic AcidBrain NeoplasmsFemaleFluorescenceFluorometryGliomaHumansIntraoperative PeriodLightingMagnetic Resonance ImagingMaleMiddle AgedPorphyrinsSensitivity and Specificity

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679

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Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial