review Open AccessTop 1% cited
Synonymous but not the same: the causes and consequences of codon bias
Nature Reviews Genetics · 2010 · Vol. 12(1) · pp. 32–42
Joshua B. Plotkin✉(Philadelphia University)Grzegorz Kudla(University of Edinburgh)
RNA and protein synthesis mechanismsGenomics and Phylogenetic StudiesRNA modifications and cancerBiologyCodon usage biasEvolutionary biologyGeneticsComputational biologyGeneGenome
MeSH terms
MiceAnimalsCodonHumansMutationProtein BiosynthesisGene ExpressionGenomeDrosophila Proteins
Funding
- David and Lucile Packard Foundation
- Burroughs Wellcome Fund
- Alfred P. Sloan Foundation
- James S. McDonnell Foundation
- Wellcome Trust
- Defense Advanced Research Projects Agency
- Advanced Research Projects Agency
- National Institute of Allergy and Infectious Diseases
Citations
1,743
FWCI
30.70
field-weighted impact
References
148
Percentile
100%
vs. same field & year
Citations per year
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References
Correlation between the abundance of Escherichia coli transfer RNAs and the occurrence of the respective codons in its protein genes: A proposal for a synonymous codon choice that is optimal for the E. coli translational system
Journal of Molecular Biology · 1981 · 1,452 citations
Tissue-Specific Differences in Human Transfer RNA Expression
PLoS Genetics · 2006 · 615 citations
Transient ribosomal attenuation coordinates protein synthesis and co-translational folding
Nature Structural & Molecular Biology · 2009 · 561 citations
Synonymous mutations in the human dopamine receptor D2 (DRD2) affect mRNA stability and synthesis of the receptor
Human Molecular Genetics · 2003 · 923 citations
The selection-mutation-drift theory of synonymous codon usage.
Genetics · 1991 · 1,037 citations
Prediction of Mammalian MicroRNA Targets
Cell · 2003 · 5,174 citations
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