article Open AccessTop 1% cited
Nrf2 regulates ROS production by mitochondria and NADPH oxidase
Biochimica et Biophysica Acta (BBA) - General Subjects · 2014 · Vol. 1850(4) · pp. 794–801
Stjepana Kovac(University College London)Plamena R. Angelova(National Hospital for Neurology and Neurosurgery)Kira M. Holmström(National Hospital for Neurology and Neurosurgery)Ying Zhang(Ninewells Hospital)Albena T. Dinkova‐Kostova✉(Johns Hopkins University)Andrey Y. Abramov✉(National Hospital for Neurology and Neurosurgery)
Abstract
Findings supports a key role of the Keap1-Nrf2 pathway in redox homeostasis within the cell.
Genomics, phytochemicals, and oxidative stressCircadian rhythm and melatoninGlutathione Transferases and PolymorphismsKEAP1Cell biologyNADPH oxidaseNOX4Transcription factorMitochondrial ROSMitochondrionGene knockdownDownregulation and upregulationReactive oxygen species
MeSH terms
Kelch-Like ECH-Associated Protein 1AnimalsCytosolMice, HairlessMitochondriaReactive Oxygen SpeciesNADPH OxidasesIntracellular Signaling Peptides and ProteinsNF-E2-Related Factor 2Mice
Funding
- Medical Research Council
Citations
580
FWCI
13.38
field-weighted impact
References
65
Percentile
99%
vs. same field & year
Citations per year
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References
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Brain · 2011 · 1,153 citations
Oxidative stress and neurodegeneration: where are we now?
Journal of Neurochemistry · 2006 · 2,577 citations
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