article Open AccessTop 1% cited
High-speed optical frequency-domain imaging
Optics Express · 2003 · Vol. 11(22) · pp. 2953–2953
Seok‐Hyun Yun✉(Harvard University)G. J. Tearney(Harvard University)Johannes F. de Boer(Massachusetts General Hospital)Nicusor Iftimia(Harvard University)B. E. Bouma(Harvard University)
Abstract
We demonstrate high-speed, high-sensitivity, high-resolution optical imaging based on optical frequency-domain interferometry using a rapidly-tuned wavelength-swept laser. We derive and show experimentally that frequency-domain ranging provides a superior signal-to-noise ratio compared with conventional time-domain ranging as used in optical coherence tomography. A high sensitivity of -110 dB was obtained with a 6 mW source at an axial resolution of 13.5 microm and an A-line rate of 15.7 kHz, representing more than an order-of-magnitude improvement compared with previous OCT and interferometric imaging methods.
Optical Coherence Tomography ApplicationsPhotoacoustic and Ultrasonic ImagingAdvanced Fluorescence Microscopy TechniquesOpticsOptical coherence tomographyInterferometryRangingSensitivity (control systems)Frequency domainLaserWavelengthCoherence (philosophical gambling strategy)Signal-to-noise ratio (imaging)
Funding
- National Science Foundation
- Massachusetts General Hospital
- Consortia for Improving Medicine with Innovation and Technology
Citations
856
FWCI
26.27
field-weighted impact
References
25
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100%
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References
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Optics Express · 2003 · 1,824 citations
Improved signal-to-noise ratio in spectral-domain compared with time-domain optical coherence tomography
Optics Letters · 2003 · 1,241 citations
Optical coherence tomography using a frequency-tunable optical source
Optics Letters · 1997 · 651 citations
Sensitivity advantage of swept source and Fourier domain optical coherence tomography
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Measurement of intraocular distances by backscattering spectral interferometry
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