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Elastic Modulus Determination of Normal and Glaucomatous Human Trabecular Meshwork

Investigative Ophthalmology & Visual Science · 2011 · Vol. 52(5) · pp. 2147–2147

Julie A. Last✉(University of Wisconsin–Madison)Tingrui Pan✉(Centre for Biomedical Engineering and Physics)Yuzhe Ding✉(Centre for Biomedical Engineering and Physics)Christopher M. Reilly✉(Bipar)Kate E. Keller✉(Oregon Health & Science University)Ted S. Acott✉(Oregon Health & Science University)Michael P. Fautsch✉(Mayo Clinic)Christopher J. Murphy✉(University of California, Davis)Paul Russell✉(University of California, Davis)

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Abstract

The data indicate that the stiffness of glaucomatous HTM is significantly increased compared with that of normal HTM. Modeling exercises support substantial impairment in outflow facility with increased HTM stiffness. Alterations in the biophysical attributes of the HTM may participate directly in the onset and progression of glaucoma.

Glaucoma and retinal disorders Cellular Mechanics and Interactions Corneal surgery and disordersTrabecular meshworkGlaucomaStiffnessIntraocular pressureOphthalmologyElastic modulusMaterials scienceModulusMedicineComposite material

MeSH terms

AdultAgedAged, 80 and overElasticityGlaucoma, Open-AngleHumansMiddle AgedModels, TheoreticalTrabecular MeshworkMicroscopy, Atomic ForceElastic Modulus