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Rotenone destroys dopaminergic neurons and induces parkinsonian symptoms in rats

Behavioural Brain Research · 2002 · Vol. 136(1) · pp. 317–324
Mesbah AlamWerner Schmidt
Parkinson's Disease Mechanisms and TreatmentsBiochemical and biochemical processesNeuroscience and Neuropharmacology ResearchRotenoneDopaminergicNeurochemicalStriatumDopamineTyrosine hydroxylaseParkinson's diseaseNeurodegenerationIntraperitoneal injectionNeuroscience

MeSH terms

AnimalsBehavior, AnimalCatalepsyChromatography, High Pressure LiquidDopamineElectrochemistryImmunohistochemistryMaleNeuronsParkinson Disease, SecondaryRotenoneTyrosine 3-MonooxygenaseUncoupling AgentsBlotting, WesternNeostriatum

Funding

  • Deutsche Forschungsgemeinschaft
Citations
473
FWCI
10.62
field-weighted impact
References
11
Percentile
99%
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Citations per year
References
Mitochondrial Complex I Deficiency in Parkinson's Disease
Journal of Neurochemistry · 1990 · 2,261 citations
A rapid method for the regional dissection of the rat brain
Pharmacology Biochemistry and Behavior · 1980 · 542 citations
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Rotenone destroys dopaminergic neurons and induces parkinsonian symptoms in rats · Scinovex