articleTop 1% cited
Alginate/Chitosan Nanoparticles are Effective for Oral Insulin Delivery
Pharmaceutical Research · 2007 · Vol. 24(12) · pp. 2198–2206
Bruno Sarmento✉(Universidade do Porto)António J. Ribeiro(University of Coimbra)Francisco Veiga(University of Coimbra)Paula Sampaio(Universidade do Porto)R. Neufeld(Queen's University)Domingos Ferreira(Universidade do Porto)
Advanced Drug Delivery SystemsDrug Solubulity and Delivery SystemsAdvancements in Transdermal Drug DeliveryInsulinChitosanChemistryOral administrationPharmacologyNanoparticleIn vivoIonotropic effectDosage formConfocal microscopy
MeSH terms
Administration, OralAlginatesAnimalsBiological AvailabilityBlood GlucoseChemistry, PharmaceuticalDiabetes Mellitus, ExperimentalDose-Response Relationship, DrugDrug CarriersDrug CompoundingHexuronic AcidsHydrogen-Ion ConcentrationHypoglycemic AgentsInsulinIntestinal Absorption
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609
FWCI
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55
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99%
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References
The Oral Absorption of Micro- and Nanoparticulates: Neither Exceptional Nor Unusual
Pharmaceutical Research · 1997 · 495 citations
Effect of Chitosan on the Permeability of Monolayers of Intestinal Epithelial Cells (Caco-2)
Pharmaceutical Research · 1994 · 768 citations
Protein Instability in Poly(Lactic-co-Glycolic Acid) Microparticles
Pharmaceutical Research · 2000 · 696 citations
Chitosan as a Novel Nasal Delivery System for Peptide Drugs
Pharmaceutical Research · 1994 · 620 citations
Colloidal drug delivery systems
Colloids and Surfaces B Biointerfaces · 1995 · 419 citations
Bioadhesive polysaccharide in protein delivery system: chitosan nanoparticles improve the intestinal absorption of insulin in vivo
International Journal of Pharmaceutics · 2002 · 685 citations
Protein release from alginate matrices
Advanced Drug Delivery Reviews · 1998 · 1,522 citations
Polyionic hydrocolloids for the intestinal delivery of protein drugs: Alginate and chitosan — a review
Journal of Controlled Release · 2006 · 1,941 citations
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