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Bioadhesive polysaccharide in protein delivery system: chitosan nanoparticles improve the intestinal absorption of insulin in vivo

International Journal of Pharmaceutics · 2002 · Vol. 249(1-2) · pp. 139–147

Yan Pan(Shenyang Pharmaceutical University)Ying-jian Li(Shenyang Pharmaceutical University)Hui-ying Zhao(Shenyang Pharmaceutical University)Jun-min Zheng✉(Shenyang Pharmaceutical University)Hui Xu(Shenyang Pharmaceutical University)Gang Wei(Shenyang Pharmaceutical University)Jin-song Hao(National University of Singapore)Fu-De Cui(Shenyang Pharmaceutical University)

View via DOI Publisher page

Advanced Drug Delivery Systems Proteins in Food Systems Infant Nutrition and HealthBioavailabilityBioadhesiveChemistryInsulinChitosanAbsorption (acoustics)Zeta potentialIn vivoOral administrationNanoparticle

MeSH terms

AdhesivesAnimalsBlood GlucoseChitinInsulinIntestinal AbsorptionMalePolysaccharidesDrug Delivery SystemsRats, WistarNanotechnologyChitosanRats

Citations

685

FWCI

7.78

field-weighted impact

References

25

Percentile

99%

vs. same field & year

Citations per year

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References

Chitosan-Based Vector/DNA Complexes for Gene Delivery: Biophysical Characteristics and Transfection Ability

Pharmaceutical Research · 1998 · 533 citations

Chitosan and Chitosan/Ethylene Oxide-Propylene Oxide Block Copolymer Nanoparticles as Novel Carriers for Proteins and Vaccines

Pharmaceutical Research · 1997 · 808 citations

Enhancement of Nasal Absorption of Insulin Using Chitosan Nanoparticles

Pharmaceutical Research · 1999 · 586 citations

Effect of Chitosan on the Permeability of Monolayers of Intestinal Epithelial Cells (Caco-2)

Pharmaceutical Research · 1994 · 768 citations

Chitosans as Absorption Enhancers for Poorly Absorbable Drugs 2: Mechanism of Absorption Enhancement

Pharmaceutical Research · 1997 · 581 citations

Novel hydrophilic chitosan-polyethylene oxide nanoparticles as protein carriers

Journal of Applied Polymer Science · 1997 · 1,818 citations

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Bioadhesive polysaccharide in protein delivery system: chitosan nanoparticles improve the intestinal absorption of insulin in vivo · Scinovex