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Dissecting the bacterial type VI secretion system by a genome wide in silico analysis: what can be learned from available microbial genomic resources?
BMC Genomics · 2009 · Vol. 10(1) · pp. 104–104
Frédéric Boyer(Laboratoire de Chimie et Biologie des Métaux)Gwennaële Fichant(Université Toulouse III - Paul Sabatier)Jérémie Berthod(Commissariat à l'Énergie Atomique et aux Énergies Alternatives)Yves Vandenbrouck(Commissariat à l'Énergie Atomique et aux Énergies Alternatives)Ina Attrée✉(Université Joseph Fourier)
Abstract
The core of T6SS is composed of 13 proteins, conserved in both pathogenic and non-pathogenic bacteria. Subclasses of T6SS differ in regulatory and accessory protein content suggesting that T6SS has evolved to adapt to various microenvironments and specialized functions. Based on these results, new functional hypotheses concerning the assembly and function of T6SS proteins are proposed.
Vibrio bacteria research studiesEscherichia coli research studiesAntibiotic Resistance in BacteriaBiologyType VI secretion systemGenomeGeneticsIn silicoPhylogenetic treeGeneHorizontal gene transferComputational biologyConserved sequence
MeSH terms
BacteriaBacterial ProteinsChromosome MappingGenes, BacterialMultigene FamilyPhylogenyGenome, BacterialEvolution, MolecularProtein TransportGenomics
Funding
- Centre National de la Recherche Scientifique
Citations
576
FWCI
16.83
field-weighted impact
References
53
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100%
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References
A General Empirical Model of Protein Evolution Derived from Multiple Protein Families Using a Maximum-Likelihood Approach
Molecular Biology and Evolution · 2001 · 2,937 citations
A Simple, Fast, and Accurate Algorithm to Estimate Large Phylogenies by Maximum Likelihood
Systematic Biology · 2003 · 16,911 citations
Conservation of gene order: a fingerprint of proteins that physically interact
Trends in Biochemical Sciences · 1998 · 1,055 citations
MUSCLE: multiple sequence alignment with high accuracy and high throughput
Nucleic Acids Research · 2004 · 45,964 citations
Predicting transmembrane protein topology with a hidden markov model: application to complete genomes11Edited by F. Cohen
Journal of Molecular Biology · 2001 · 12,890 citations
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs
Nucleic Acids Research · 1997 · 74,154 citations
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