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Resistant hypertension? Assessment of adherence by toxicological urine analysis

Journal of Hypertension · 2013 · Vol. 31(4) · pp. 766–774

Oliver Jung✉(Goethe University Frankfurt)Janis L. GechterCora Wunder(Goethe University Frankfurt)Alexander Paulke(Goethe University Frankfurt)Christine BartelHelmut GeigerStefan W. Toennes(Goethe University Frankfurt)

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Abstract

Low adherence was the most common cause of poor blood pressure control in patients with apparent resistant hypertension, being twice as frequent as secondary causes of hypertension. Incomplete adherence was far more common than complete nonadherence; thus, assessment of adherence in patients on multiple drug regime is only reliable when all drugs are included in assessment. Assessing adherence by toxicological urine screening is a useful tool in detecting low adherence, especially in the setting of multidrug regimen as a cause of apparently resistant hypertension.

Blood Pressure and Hypertension Studies Pharmacological Effects and Toxicity Studies Medication Adherence and ComplianceMedicineBlood pressureRegimenInternal medicineResistant hypertensionSecondary hypertensionAntihypertensive drugUrine

MeSH terms

AgedAntihypertensive AgentsChromatography, High Pressure LiquidDrug Therapy, CombinationFemaleHumansHypertensionMaleMiddle AgedPatient ComplianceSpectrometry, Mass, Electrospray Ionization

Citations

465

FWCI

40.65

field-weighted impact

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100%

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Citations per year

Cited by

2018 ESC/ESH Guidelines for the management of arterial hypertension