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An Architectural Role for a Nuclear Noncoding RNA: NEAT1 RNA Is Essential for the Structure of Paraspeckles

Molecular Cell · 2009 · Vol. 33(6) · pp. 717–726

Christine Clemson✉(University of Massachusetts Chan Medical School)John N. Hutchinson(Harvard University)Sergio Andres Sara(University of Western Australia)Alexander W. Ensminger(Harvard University)Archa H. Fox(University of Western Australia)Andrew Chess(Harvard University)Jeanne B. Lawrence(University of Massachusetts Chan Medical School)

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RNA regulation and disease RNA Research and Splicing RNA and protein synthesis mechanismsRNABiologyCell biologyNon-coding RNASmall nuclear RNASignal recognition particle RNALong non-coding RNAGeneticsGene

MeSH terms

AnimalsCell NucleusCells, CulturedEndoribonucleasesHumansNuclear ProteinsRNA, Small NuclearRNA-Binding ProteinsRNA InterferenceIntranuclear Inclusion BodiesImmunoprecipitationMiceGene Knockdown TechniquesChloroplast Proteins

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NEAT1 long noncoding RNA regulates transcription via protein sequestration within subnuclear bodies