article Open AccessTop 10% cited
A screen for nuclear transcripts identifies two linked noncoding RNAs associated with SC35 splicing domains
BMC Genomics · 2007 · Vol. 8(1) · pp. 39–39
John N. Hutchinson✉(Harvard University)Alexander W. Ensminger(Center for Human Genetics)Christine Clemson(University of Massachusetts Chan Medical School)Christopher R. Lynch(University of Massachusetts Chan Medical School)Jeanne B. Lawrence(University of Massachusetts Chan Medical School)Andrew Chess(Harvard University)
Abstract
Our genome-wide screens in two mammalian species reveal no more than three abundant large non-coding polyadenylated RNAs in the nucleus; the canonical large noncoding RNA XIST and NEAT1 and NEAT2. The function of these noncoding RNAs in mRNA metabolism is suggested by their high levels of conservation and their intimate association with SC35 splicing domains in multiple mammalian species.
Cancer-related molecular mechanisms researchRNA Research and SplicingRNA modifications and cancerBiologyXISTLong non-coding RNARNASmall nucleolar RNAGeneticsNon-coding RNAPolyadenylationRNA splicingIntron
MeSH terms
AnimalsBase SequenceCell NucleusChromosome MappingHumansIntronsRNA SplicingRNA, MessengerSubcellular FractionsDNA PrimersEvolution, MolecularOligonucleotide Array Sequence AnalysisMice
Funding
- Howard Hughes Medical Institute
- National Institutes of Health
Citations
1,002
FWCI
8.91
field-weighted impact
References
47
Percentile
98%
vs. same field & year
Citations per year
Cited by
NEAT1 long noncoding RNA regulates transcription via protein sequestration within subnuclear bodies
Molecular Biology of the Cell · 2013 · 474 citations
Long non-coding RNA NEAT1 promotes non-small cell lung cancer progression through regulation of miR-377-3p-E2F3 pathway
Oncotarget · 2016 · 322 citations
Noncoding RNA:RNA Regulatory Networks in Cancer
International Journal of Molecular Sciences · 2018 · 1,069 citations
The Noncoding RNA <i>MALAT1</i> Is a Critical Regulator of the Metastasis Phenotype of Lung Cancer Cells
Cancer Research · 2012 · 1,556 citations
Biogenesis and function of nuclear bodies
Trends in Genetics · 2011 · 680 citations
Cellular functions of long noncoding RNAs
Nature Cell Biology · 2019 · 1,451 citations
The lncRNA Malat1 Is Dispensable for Mouse Development but Its Transcription Plays a cis-Regulatory Role in the Adult
Cell Reports · 2012 · 604 citations
Unique features of long non-coding RNA biogenesis and function
Nature Reviews Genetics · 2015 · 3,867 citations
References
Gene Expression Omnibus: NCBI gene expression and hybridization array data repository
Nucleic Acids Research · 2002 · 13,655 citations
Non-coding RNA
Human Molecular Genetics · 2006 · 2,447 citations
MALAT-1, a novel noncoding RNA, and thymosin β4 predict metastasis and survival in early-stage non-small cell lung cancer
Oncogene · 2003 · 2,171 citations
<tt>BLAT</tt>—The <tt>BLAST</tt>-Like Alignment Tool
Genome Research · 2002 · 8,404 citations
Citation Network
How this paper connects to the literature. Drag to explore, click any node to open that paper.