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Macrophage Depletion Inhibits Experimental Choroidal Neovascularization

Investigative Ophthalmology & Visual Science · 2003 · Vol. 44(8) · pp. 3578–3578

Eiji Sakurai✉(University of Kentucky)Akshay Anand(University of Kentucky)Balamurali K. Ambati(Augusta University)Nico van Rooijen(Vrije Universiteit Amsterdam)Jayakrishna Ambati(University of Kentucky)

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Abstract

Generalized macrophage depletion reduced the size and leakage of laser-induced CNV and was associated with decreased macrophage infiltration and VEGF protein. These findings define the role of the macrophage as a critical component in initiating the laser-induced CNV response.

Retinal Diseases and Treatments Glaucoma and retinal disorders Corneal surgery and disordersChoroidal neovascularizationImmunostainingLesionMedicineNeovascularizationVascular endothelial growth factorFluorescein angiographyOphthalmologyInfiltration (HVAC)Macrophage

MeSH terms

AnimalsAntigens, DifferentiationAntimetabolitesCell MovementClodronic AcidDisease Models, AnimalEnzyme-Linked Immunosorbent AssayFluorescein AngiographyLiposomesLymphokinesMacrophagesMaleMice, Inbred C57BLEndothelial Growth FactorsChoroidal Neovascularization