articleTop 10% cited
HER2 signaling pathway activation and response of breast cancer cells to HER2-targeting agents is dependent strongly on the 3D microenvironment
Breast Cancer Research and Treatment · 2009 · Vol. 122(1) · pp. 35–43
Britta Weigelt✉(Cancer Research UK)Alvin Lo(Lawrence Berkeley National Laboratory)Catherine C. Park(University of California, Berkeley)Joe W. Gray(University of California, Berkeley)Mina J. Bissell(University of California, Berkeley)
HER2/EGFR in Cancer ResearchMonoclonal and Polyclonal Antibodies ResearchCellular Mechanics and InteractionsLapatinibPertuzumabTrastuzumabCancer researchSKBR3Tumor microenvironmentSignal transductionPI3K/AKT/mTOR pathwayCell biologyCell signaling
MeSH terms
TrastuzumabLapatinibAntibodies, MonoclonalAntineoplastic AgentsCell DivisionCell SurvivalEnzyme ActivationExtracellular MatrixFemaleGelsHumansLamininNeoplasm ProteinsQuinazolinesSignal Transduction
Citations
332
FWCI
8.12
field-weighted impact
References
39
Percentile
98%
vs. same field & year
Citations per year
Cited by
A Comprehensive Review on MAPK: A Promising Therapeutic Target in Cancer
Cancers · 2019 · 925 citations
3D Cell Culture Systems: Advantages and Applications
Journal of Cellular Physiology · 2014 · 1,171 citations
Potential role of HER2‐overexpressing exosomes in countering trastuzumab‐based therapy
Journal of Cellular Physiology · 2011 · 501 citations
Doxorubicin resistance in breast cancer cells is mediated by extracellular matrix proteins
BMC Cancer · 2018 · 342 citations
Tumor microenvironment and therapeutic response
Cancer Letters · 2016 · 1,857 citations
References
Untangling the ErbB signalling network
Nature Reviews Molecular Cell Biology · 2001 · 6,890 citations
Putting tumours in context
Nature reviews. Cancer · 2001 · 2,159 citations
The third dimension bridges the gap between cell culture and live tissue
Nature Reviews Molecular Cell Biology · 2007 · 2,734 citations
PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients
Cancer Cell · 2004 · 1,856 citations
Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2/<i>neu</i>Oncogene
Science · 1987 · 11,680 citations
A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes
Cancer Cell · 2006 · 3,214 citations
Citation Network
How this paper connects to the literature. Drag to explore, click any node to open that paper.