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Recursive partitioning analysis (RPA) of prognostic factors in three radiation therapy oncology group (RTOG) brain metastases trials

Laurie E. GasparCharles ScottMarvin RotmanSucha O. AsbellTheodore L. PhillipsTodd H. WassermanW. Gillies McKennaRoger W. Byhardt

Abstract

Based on this analysis, we suggest the following three classes: Class 1: patients with KPS > or = 70, < 65 years of age with controlled primary and no extracranial metastases; Class 3: KPS < 70; Class 2- all others. Using these classes or stages, new treatment techniques can be tested on homogeneous patient groups.

Brain Metastases and TreatmentLung Cancer Research StudiesLung Cancer Treatments and MutationsRecursive partitioningMedicineRadiosurgeryRadiation therapyHomogeneousOncologyInternal medicineStatistical significancePrognostic variableKarnofsky Performance Status

MeSH terms

AdultAge FactorsAgedBrain NeoplasmsDecision TreesHumansMiddle AgedNervous System DiseasesPrognosisRadiotherapy DosageRetrospective StudiesSurvival AnalysisRandomized Controlled Trials as TopicClinical Trials, Phase I as TopicClinical Trials, Phase II as Topic
Citations
2,550
FWCI
11.46
field-weighted impact
References
27
Percentile
99%
vs. same field & year
Citations per year
References
A multi-institutional experience with stereotactic radiosurgery for solitary brain metastasis
International Journal of Radiation Oncology*Biology*Physics · 1994 · 702 citations
The choice of treatment of single brain metastasis should be based on extracranial tumor activity and age
International Journal of Radiation Oncology*Biology*Physics · 1994 · 635 citations
Nonparametric Estimation from Incomplete Observations
Journal of the American Statistical Association · 1958 · 38,793 citations
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