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Adipocytic proportion of bone marrow is inversely related to bone formation in osteoporosis

Journal of Clinical Pathology · 2002 · Vol. 55(9) · pp. 693–698

Shashi Kant Verma(University of Manchester)J H Rajaratnam(University of Manchester)J Denton(University of Manchester)J A Hoyland(University of Manchester)R J Byers✉(University of Manchester)

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Abstract

Cancellous apposition rate, osteoid volume, and age were associated with the increase in the proportion of adipose tissue present in OP bone. Of these, cancellous apposition rate reflects osteoblast activity, indicating that the increase in the volume of adipose tissue in osteoporosis is associated with reduced bone formation, supporting the postulated switch in differentiation of stromal cells from the osteoblastic to the adipocytic pathway in osteoporosis.

Bone and Joint Diseases Bone health and osteoporosis research Hematological disorders and diagnosticsCancellous boneIliac crestOsteoidAppositionOsteoporosisStromal cellAdipose tissueBone marrowMedicineBone tissue

MeSH terms

AdolescentAdultAgedAged, 80 and overBiopsyBone Marrow CellsCell DifferentiationChildChild, PreschoolFemaleHumansImage Processing, Computer-AssistedMaleMiddle AgedOsteogenesis

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421

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3.90

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93%

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Cited by

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