articleTop 1% cited

Fruit juices inhibit organic anion transporting polypeptide–mediated drug uptake to decrease the oral availability of fexofenadine

Clinical Pharmacology & Therapeutics · 2002 · Vol. 71(1) · pp. 11–20

George K. Dresser(Wake Forest University)David G. Bailey✉(Wake Forest University)Brenda F. Leake(Vanderbilt University)Ute I. Schwarz(Western University)Paul A. Dawson(Wake Forest University)David J. Freeman(Vanderbilt University)Richard B. Kim(Vanderbilt University)

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Abstract

Fruit juices and constituents are more potent inhibitors of OATPs than P-glycoprotein activities, which can reduce oral drug bioavailability. Results support a new model of intestinal drug absorption and mechanism of food-drug interaction.

Drug Transport and Resistance Mechanisms Gastroesophageal reflux and treatments Antibiotics Pharmacokinetics and EfficacyGrapefruit juiceFexofenadineChemistryPharmacokineticsOrganic anion-transporting polypeptidePharmacologyOrganic anion transporter 1AspartameFood scienceCrossover study

MeSH terms

Administration, OralAdultBeveragesBiological AvailabilityCarrier ProteinsCitrusDouble-Blind MethodFemaleFlavonoidsFruitHeLa CellsHistamine H1 AntagonistsHumansIntestinal AbsorptionMale

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606

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15.21

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Bile acid transporters