articleTop 10% cited
Determination of drug permeability and prediction of drug absorption in Caco-2 monolayers
Nature Protocols · 2007 · Vol. 2(9) · pp. 2111–2119
Ina Hubatsch✉(Uppsala University)Eva Ragnarsson(Uppsala University)Per Artursson(Uppsala University)
Drug Transport and Resistance MechanismsDrug Solubulity and Delivery SystemsPharmacological Effects and Toxicity StudiesCaco-2Permeability (electromagnetism)MonolayerDrugXenobioticChemistryBioavailabilityAbsorption (acoustics)BiophysicsChromatography
Funding
- Vetenskapsrådet
Citations
1,427
FWCI
7.20
field-weighted impact
References
28
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98%
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References
Characterization of the Human Colon Carcinoma Cell Line (Caco-2) as a Model System for Intestinal Epithelial Permeability
Gastroenterology · 1989 · 2,193 citations
Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells
Biochemical and Biophysical Research Communications · 1991 · 1,852 citations
Caco-2 monolayers in experimental and theoretical predictions of drug transport1PII of original article: S0169-409X(96)00415-2. The article was originally published in Advanced Drug Delivery Reviews 22 (1996) 67–84.1
Advanced Drug Delivery Reviews · 2001 · 1,524 citations
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