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Cancer Incidence in BRCA1 Mutation Carriers
JNCI Journal of the National Cancer Institute · 2002 · Vol. 94(18) · pp. 1358–1365
Douglas Thompson✉(Cancer Research UK)
Abstract
In carriers of BRCA1 mutations, the overall increased risk of cancer at sites other than breast and ovary is small and is observed in women but generally not in men. BRCA1 mutations may confer increased risks of other abdominal cancers in women and increased risks of pancreatic cancer in men and women.
BRCA gene mutations in cancerGenomic variations and chromosomal abnormalitiesCancer Genomics and DiagnosticsCancerMutationIncidence (geometry)MedicineCancer researchOncologyGeneticsInternal medicineBiologyGene
MeSH terms
Age FactorsAgedBreast NeoplasmsFemaleGenetic Carrier ScreeningHumansMaleMiddle AgedMutationNeoplasmsRiskSex CharacteristicsGenes, BRCA1
Citations
1,084
FWCI
20.03
field-weighted impact
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48
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References
Prevalence and Penetrance of Germline BRCA1 and BRCA2 Mutations in a Population Series of 649 Women with Ovarian Cancer
The American Journal of Human Genetics · 2001 · 992 citations
Endometrial Cancer in Tamoxifen-Treated Breast Cancer Patients: Findings From the National Surgical Adjuvant Breast and Bowel Project (NSABP) B-14 *
JNCI Journal of the National Cancer Institute · 1994 · 1,275 citations
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