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Transgenerational effects of prenatal exposure to the Dutch famine on neonatal adiposity and health in later life

BJOG An International Journal of Obstetrics & Gynaecology · 2008 · Vol. 115(10) · pp. 1243–1249

RC Painter(University of Amsterdam)Clive Osmond(University of Southampton)Peter D. Gluckman(University of Auckland)Mark A. Hanson(University of Southampton)DIW Phillips(University of Southampton)Tessa J. Roseboom✉(Academic Medical Center)

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Abstract

We did not find transgenerational effects of prenatal exposure to famine on birthweight nor on cardiovascular and metabolic disease rates. F1 famine exposure in utero was, however, associated with increased F2 neonatal adiposity and poor health in later life. Our findings may imply that the increase in chronic disease after famine exposure in utero is not limited to the F1 generation but persists in the F2 generation.

Birth, Development, and Health Pregnancy and preeclampsia studies Gestational Diabetes Research and ManagementFamineOffspringIn uteroMedicineCohortPregnancyConfoundingCohort studyDemographyPopulation

MeSH terms

Birth WeightCardiovascular DiseasesFemaleHealth StatusHumansMaleMetabolic DiseasesMiddle AgedNetherlandsPregnancyPrenatal Exposure Delayed EffectsStarvationCohort StudiesMultivariate AnalysisMaternal Nutritional Physiological Phenomena

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Transgenerational effects of prenatal exposure to the 1944–45 Dutch famine