articleTop 1% cited
Transgenerational effects of prenatal exposure to the 1944–45 Dutch famine
BJOG An International Journal of Obstetrics & Gynaecology · 2013 · Vol. 120(5) · pp. 548–554
MVE Veenendaal✉(University of Amsterdam)R.C. Painter(University of Amsterdam)Susanne R. de Rooij(University of Amsterdam)PMM Bossuyt(University of Amsterdam)Joris van der Post(University of Amsterdam)P. D. Gluckman(University of Auckland)Mark A. Hanson(University of Southampton)Tessa J. Roseboom(University of Amsterdam)
Abstract
Offspring of prenatally undernourished fathers, but not mothers, were heavier and more obese than offspring of fathers and mothers who had not been undernourished prenatally. We found no evidence of transgenerational effects of grandmaternal under-nutrition during gestation on the health of this relatively young group, but the increased adiposity in the offspring of prenatally undernourished fathers may lead to increased chronic disease rates in the future.
Birth, Development, and HealthObesity, Physical Activity, DietGestational Diabetes Research and ManagementOffspringPregnancyTransgenerational epigeneticsFamineMedicineBody mass indexCohortGestationPopulationCohort study
MeSH terms
AdultBody CompositionBody WeightFemaleHumansMaleNetherlandsPregnancyPrenatal Exposure Delayed EffectsSurveys and QuestionnairesStarvationCohort StudiesBody Mass IndexHistory, 20th CenturyAdiposity
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References
Transgenerational effects of prenatal exposure to the Dutch famine on neonatal adiposity and health in later life
BJOG An International Journal of Obstetrics & Gynaecology · 2008 · 719 citations
DNA methylation differences after exposure to prenatal famine are common and timing- and sex-specific
Human Molecular Genetics · 2009 · 1,143 citations
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