article Open AccessTop 1% cited
Downregulation of β-catenin by human Axin and its association with the APC tumor suppressor, β-catenin and GSK3β
Current Biology · 1998 · Vol. 8(10) · pp. 573–581
Wnt/β-catenin signaling in development and cancerCancer-related gene regulationGenetic factors in colorectal cancerAdenomatous polyposis coliWnt signaling pathwayBiologyDownregulation and upregulationGSK-3CateninBeta-cateninCarcinogenesisAXIN2Cancer research
MeSH terms
Proto-Oncogene MasCell LineCytoskeletal ProteinsHumansPhosphorylationAdenomatous Polyposis ColiProteinsRepressor ProteinsTumor Cells, CulturedTrans-ActivatorsDown-RegulationCalcium-Calmodulin-Dependent Protein KinasesAdenomatous Polyposis Coli ProteinXenopus ProteinsGlycogen Synthase Kinases
Funding
- National Institutes of Health
Citations
844
FWCI
24.37
field-weighted impact
References
39
Percentile
100%
vs. same field & year
Citations per year
Cited by
Negative Feedback Loop of Wnt Signaling through Upregulation of Conductin/Axin2 in Colorectal and Liver Tumors
Molecular and Cellular Biology · 2002 · 1,033 citations
Wnt signaling in development and tissue homeostasis
Development · 2018 · 826 citations
Wnt signaling and cancer
Genes & Development · 2000 · 3,172 citations
Wnt/β-Catenin/Tcf Signaling Induces the Transcription of Axin2, a Negative Regulator of the Signaling Pathway
Molecular and Cellular Biology · 2002 · 1,666 citations
The Role of the Extracellular Matrix and Its Molecular and Cellular Regulators in Cancer Cell Plasticity
Frontiers in Oncology · 2018 · 375 citations
GSK3 takes centre stage more than 20 years after its discovery
Biochemical Journal · 2001 · 1,294 citations
Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling
Biochemical Journal · 2001 · 1,676 citations
The ABC of APC
Human Molecular Genetics · 2001 · 875 citations
References
Wnt signaling: a common theme in animal development
Genes & Development · 1997 · 2,571 citations
Lessons from Hereditary Colorectal Cancer
Cell · 1996 · 4,911 citations
Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta -catenin and promotes GSK-3beta -dependent phosphorylation of beta -catenin
The EMBO Journal · 1998 · 1,249 citations
Somatic mutations of the <i>APC</i> gene in colorectal tumors: mutation cluster region in the <i>APC</i> gene
Human Molecular Genetics · 1992 · 934 citations
Citation Network
How this paper connects to the literature. Drag to explore, click any node to open that paper.