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Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta -catenin and promotes GSK-3beta -dependent phosphorylation of beta -catenin
The EMBO Journal · 1998 · Vol. 17(5) · pp. 1371–1384
Satoshi Ikeda✉(Hiroshima University)
Wnt/β-catenin signaling in development and cancerCancer-related gene regulationPolyamine Metabolism and ApplicationsBiologyBeta-cateninWnt signaling pathwayPhosphorylationRegulatorGSK-3CateninNegative regulatorGSK3BBETA (programming language)
MeSH terms
Amino Acid SequenceAnimalsBrainCloning, MolecularCytoskeletal ProteinsMolecular Sequence DataPhosphorylationProtein BindingProteinsProto-Oncogene ProteinsRecombinant Fusion ProteinsRepressor ProteinsSignal TransductionTrans-ActivatorsSequence Homology, Amino Acid
Citations
1,249
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44
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References
Molecular cloning and expression of glycogen synthase kinase-3/factor A.
The EMBO Journal · 1990 · 1,349 citations
An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs
Nucleic Acids Research · 1987 · 5,158 citations
β-catenin is a target for the ubiquitin–proteasome pathway
The EMBO Journal · 1997 · 2,503 citations
A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding
Analytical Biochemistry · 1976 · 225,297 citations
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