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Mechanisms of Foxp3+ T Regulatory Cell-Mediated Suppression
Immunity · 2009 · Vol. 30(5) · pp. 636–645
Ethan M. Shevach✉(National Institute of Allergy and Infectious Diseases)
T-cell and B-cell ImmunologyImmune Cell Function and InteractionImmune Response and InflammationBiologyFOXP3Immune systemCytolysisCell biologySuppressorImmunologyRegulatory T cellIn vivoAntigen
MeSH terms
AnimalsAntigen-Presenting CellsFibrinogenHumansImmune ToleranceInterleukin-2Antigens, CDT-Lymphocyte SubsetsTransforming Growth Factor betaGalectin 1NeuropilinsT-Lymphocytes, RegulatoryMiceForkhead Transcription FactorsCTLA-4 Antigen
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References
Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells
Nature Immunology · 2010 · 5,839 citations
CD4+CD25+ Immunoregulatory T Cells Suppress Polyclonal T Cell Activation In Vitro by Inhibiting Interleukin 2 Production
The Journal of Experimental Medicine · 1998 · 2,598 citations
Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression
The Journal of Experimental Medicine · 2007 · 2,356 citations
Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor <i>Foxp3 </i>
The Journal of Experimental Medicine · 2003 · 4,596 citations
Suppressor Effector Function of CD4+CD25+ Immunoregulatory T Cells Is Antigen Nonspecific
The Journal of Immunology · 2000 · 1,225 citations
Cell Contact–Dependent Immunosuppression by Cd4+Cd25+Regulatory T Cells Is Mediated by Cell Surface–Bound Transforming Growth Factor β
The Journal of Experimental Medicine · 2001 · 1,577 citations
Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
The Journal of Immunology · 1995 · 5,432 citations
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