article Open AccessTop 1% cited
A Randomized Controlled Trial of Acetyl Salicyclic Acid in the Secondary Prevention of Mortality from Myocardial Infarction
BMJ · 1974 · Vol. 1(5905) · pp. 436–440
P C Elwood✉Alexandra Cochrane(St Nicholas Hospital)M L BurrP M SweetnamG Williams(St Nicholas Hospital)Ellana Welsby(St Nicholas Hospital)Samantha Hughes(St Nicholas Hospital)Robert Renton(St Nicholas Hospital)
Abstract
The results of a randomized controlled trial of a single daily dose of acetyl salicylic acid (aspirin) in the prevention of reinfarction in 1,239 men who had had a recent myocardial infarct were statistically inconclusive. Nevertheless, they showed a reduction in total mortality of 12% at six months and 25% at twelve months after admission to the trial. Further trials are urgently required to establish whether or not this effect is real.
Antiplatelet Therapy and Cardiovascular DiseasesAcute Myocardial Infarction ResearchLipoproteins and Cardiovascular HealthAspirinMedicineRandomized controlled trialMyocardial infarctionSecondary preventionSalicylic acidInternal medicineCardiology
MeSH terms
Age FactorsAgedAspirinClinical Trials as TopicFollow-Up StudiesHumansMaleMiddle AgedMyocardial InfarctionPlacebosPlatelet AdhesivenessRecurrenceTime Factors
Citations
518
FWCI
19.80
field-weighted impact
References
11
Percentile
100%
vs. same field & year
Citations per year
Related articles
Citation Network
How this paper connects to the literature. Drag to explore, click any node to open that paper.