review Open AccessTop 1% cited

Immune-based mechanisms of cytotoxic chemotherapy: implications for the design of novel and rationale-based combined treatments against cancer

Cell Death and Differentiation · 2013 · Vol. 21(1) · pp. 15–25

Laura Bracci✉(Istituto Superiore di Sanità)Giovanna Schiavoni(Istituto Superiore di Sanità)Antonella Sistigu(Istituto Superiore di Sanità)Filippo Belardelli(Istituto Superiore di Sanità)

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Cancer Immunotherapy and Biomarkers Immune Cell Function and Interaction Phagocytosis and Immune RegulationImmune systemCytotoxic T cellImmunogenic cell deathBiologyCancer researchImmunologyImmunotherapyCancerCancer cellAcquired immune system

MeSH terms

AnimalsAntineoplastic AgentsDendritic CellsHumansImmunotherapyNeoplasmsCell DeathAdaptive ImmunityTumor Microenvironment

Funding

Associazione Italiana per la Ricerca sul Cancro

Citations

925

FWCI

18.67

field-weighted impact

References

142

Percentile

100%

vs. same field & year

Citations per year

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References

Sunitinib Mediates Reversal of Myeloid-Derived Suppressor Cell Accumulation in Renal Cell Carcinoma Patients

Clinical Cancer Research · 2009 · 852 citations

Coordinated regulation of myeloid cells by tumours

Nature reviews. Immunology · 2012 · 3,481 citations

5-Fluorouracil Selectively Kills Tumor-Associated Myeloid-Derived Suppressor Cells Resulting in Enhanced T Cell–Dependent Antitumor Immunity

Cancer Research · 2010 · 1,212 citations

Immunogenic death of colon cancer cells treated with oxaliplatin

Oncogene · 2009 · 1,118 citations

Toll-like receptor 4–dependent contribution of the immune system to anticancer chemotherapy and radiotherapy

Nature Medicine · 2007 · 2,933 citations

Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

New England Journal of Medicine · 2010 · 15,037 citations

Gemcitabine Selectively Eliminates Splenic Gr-1+/CD11b+ Myeloid Suppressor Cells in Tumor-Bearing Animals and Enhances Antitumor Immune Activity

Clinical Cancer Research · 2005 · 1,047 citations

M-1/M-2 Macrophages and the Th1/Th2 Paradigm

The Journal of Immunology · 2000 · 3,202 citations

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