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Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts

Nature Cell Biology · 2013 · Vol. 15(6) · pp. 637–646
Fernando CalvoNil EgeA. Grande-GarcíaSteven HooperRobert P. JenkinsShahid I. ChaudhryKevin J. HarringtonPeter WilliamsonEmad MoeendarbaryGuillaume CharrasErik Sahai
Hippo pathway signaling and YAP/TAZCellular Mechanics and InteractionsWnt/β-catenin signaling in development and cancerCell biologyMechanotransductionCancer cellCancer-Associated FibroblastsInvadopodiaCytoskeletonBiologyTranscription factorExtracellular matrixAngiogenesis

MeSH terms

YAP-Signaling ProteinsActomyosinAnimalsBreast NeoplasmsCells, CulturedEnzyme ActivationExtracellular MatrixFemaleFibroblastsHumansActin CytoskeletonMicrotubule-Associated ProteinsNADPH DehydrogenaseNeoplasm InvasivenessNeovascularization, Pathologic
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