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Tensional homeostasis and the malignant phenotype

Cancer Cell · 2005 · Vol. 8(3) · pp. 241–254
Matthew J. PaszekNastaran ZahirKandice R. JohnsonJohnathon N. LakinsGabriela I. RozenbergAmit GefenCynthia A. Reinhart‐KingSusan S. MarguliesMicah DemboDavid BoettigerDaniel A. HammerValerie M. Weaver
Cellular Mechanics and InteractionsCell Adhesion Molecules Research3D Printing in Biomedical ResearchFocal adhesionIntegrinCell biologyCytoskeletonMechanotransductionExtracellular matrixContractilityBiologyMorphogenesisAdherens junction

MeSH terms

AnimalsCytoskeletonHomeostasisNeoplasmsPhenotypeStress, Mechanical3T3 CellsStromal CellsCell Line, TumorCell ShapeMice

Funding

  • Ministerio de Economía y Competitividad
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References
Rho GTPases are over-expressed in human tumors
International Journal of Cancer · 1999 · 662 citations
Cell Movement Is Guided by the Rigidity of the Substrate
Biophysical Journal · 2000 · 3,280 citations
Cell mechanics and mechanotransduction: pathways, probes, and physiology
American Journal of Physiology-Cell Physiology · 2004 · 546 citations
Substrate flexibility regulates growth and apoptosis of normal but not transformed cells
American Journal of Physiology-Cell Physiology · 2000 · 654 citations
Focal Contacts as Mechanosensors
The Journal of Cell Biology · 2001 · 1,416 citations
Myotubes differentiate optimally on substrates with tissue-like stiffness
The Journal of Cell Biology · 2004 · 1,698 citations
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